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Pedro Manuel Azevedo Alexandrino Fernandes

Publicações :: Ver detalhe

Artigo em Revista
Artigo publicado em revista internacional
Sérgio Filipe Sousa; Pedro Alexandrino Fernandes; Maria João Ramos;
Unravelling the Mechanism of the Farnesyltransferase Enzyme
Journal of Biological Inorganic Chemistry
10
3-10
2005
Farnesyltransferase enzyme (FTase) is currently one of the most fascinating targets in cancer research. Studies in other areas, namely in the fight against parasites and viruses, have also led to very promising results. However, in spite of the thrilling achievements in the development of farnesyltransferase inhibitors (FTIs) over the past few years, the farnesylation mechanism remains, to some degree, a mystery. This review tries to shed some light on this puzzling enzyme by analyzing seven key mechanistic dilemmas, based on recent studies that have dramatically changed the way this enzyme is currently perceived.
- Não definido.
@ARTICLE {
AUTHOR="Sérgio Filipe Sousa and Pedro Alexandrino Fernandes and Maria João Ramos",
TITLE="Unravelling the Mechanism of the Farnesyltransferase Enzyme",
JOURNAL="Journal of Biological Inorganic Chemistry",
VOLUME="10",
NUMBER="",
PAGES="3-10",
MONTH="",
YEAR="2005",
NOTE="",
CITEKEY="",
ABSTRACT="Farnesyltransferase enzyme (FTase) is currently one of the most fascinating targets in cancer research. Studies in other areas, namely in the fight against parasites and viruses, have also led to very promising results. However, in spite of the thrilling achievements in the development of farnesyltransferase inhibitors (FTIs) over the past few years, the farnesylation mechanism remains, to some degree, a mystery. This review tries to shed some light on this puzzling enzyme by analyzing seven key mechanistic dilemmas, based on recent studies that have dramatically changed the way this enzyme is currently perceived. ",
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}
         
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